An enhancer of autophagy
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SMER28

Item No. 17768

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-bromo-N-2-propen-1-yl-4-quinazolinamine
CAS Number
307538-42-7
Molecular Formula
C11H10BrN3
Formula Weight
264.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mLDMSO: 30 mg/mLEthanol: 30 mg/mL
λmax
213, 296, 325, 339 nm
SMILES
BrC1=CC(C(NCC=C)=NC=N2)=C2C=C1
InChi Code
InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
InChi Key
BCPOLXUSCUFDGE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $102

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    100 mg

    $783

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    Product Description

    SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington's, Parkinson's, and Alzheimer's diseases.1,2,3 SMER28 induces clearance of amyloid-β (Aβ) peptides and the amyloid precursor protein c-terminal fragment (APP-CTF) in mouse embryonic fibroblasts (MEFs) isolated from wild-type, but not autophagy-related protein 5 knockout (Atg5-/-), mouse embryos in a concentration-dependent manner.4 It induces autophagy independently of rapamycin (Item No. 13346) in mammalian cells at a concentration of 47 µM.1 SMER28 also promotes reprogramming of fibroblasts into neural stem cells when used in combination with other chemical reagents.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sarkar, S., Perlstein, E.O., Imarisio, S., et al. Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models. Nat. Chem. Biol. 3(6), 331-338 (2007).

    2. Renna, M., Jiminez-Sanchez, M., Sarkar, S., et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. The Journal of Biological Chemisty 285(15), 11061-11067 (2010).

    3. Shen, D., Coleman, J., Chan, E., et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem. Biophys. 60(3), 173-185 (2011).

    4. Tian, Y., Bustos, V., Flajolet, M., et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. The FASEB Journal 25(6), 1934-1942 (2011).

    5. Zhang, M., Lin, Y.H., Sun, Y.J., et al. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18(5), 653-667 (2016).