A selective inhibitor of CYP2B6
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2-Phenyl-2-(1-piperidinyl)propane

Item No. 17799

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(1-methyl-1-phenylethyl)-piperidine
CAS Number
92321-29-4
Synonyms
  • 1-(α,α-dimethylbenzyl)-Piperidine
  • PPP
Molecular Formula
C14H21N
Formula Weight
203.3
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
CC(C1=CC=CC=C1)(C)N2CCCCC2
InChi Code
InChI=1S/C14H21N/c1-14(2,13-9-5-3-6-10-13)15-11-7-4-8-12-15/h3,5-6,9-10H,4,7-8,11-12H2,1-2H3
InChi Key
HORGQLWAZQOQNU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $202

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    10 mg

    $376

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    25 mg

    $820

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    Product Description

    2-Phenyl-2-(1-piperidinyl)propane is an analog of phencyclidine that acts as a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 (Ki = 5.6 µM; IC50 = 5.1 µM).1 It is 15-fold more selective for inhibition of CYP2B6 over CYP2D6 and 40-60-fold more selective for CYP2B6 over CYP1A2, CYP2A6, CYP2Cs, and CYP3A.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Walsky, R.L., and Obach, R.S. A comparison of 2-phenyl-2-(1-piperidinyl)propane (PPP), 1,1',1"-phosphinothioylidynetrisaziridine (ThioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab. Dispos. 35(11), 2053-2059 (2007).