A potent PIM-1 kinase inhibitor
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Pim-1 Inhibitor 2

Item No. 17809

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine
CAS Number
477845-12-8
Synonyms
  • PIMi II
Molecular Formula
C17H11ClN4O
Formula Weight
322.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 10 mg/ml
λmax
225, 256, 375 nm
SMILES
NC1=NC=CC(C2=CC3=C(C4=CC=C(Cl)C=C4)ON=C3C=C2)=N1
InChi Code
InChI=1S/C17H11ClN4O/c18-12-4-1-10(2-5-12)16-13-9-11(3-6-15(13)22-23-16)14-7-8-20-17(19)21-14/h1-9H,(H2,19,20,21)
InChi Key
AQVFETGXIRKVAQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

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    Product Description

    Pim-1 inhibitor 2 is a potent Pim-1 inhibitor (Ki = 91 nM) that targets the ATP-binding kinase hinge region.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pierce, A.C., Jacobs, M., and Stuver-Moody, C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J. Med. Chem. 51(6), 1972-1975 (2008).

    2. Duverger, A., Wolschendorf, F., Anderson, J.C., et al. Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation. J. Virol. 88(1), 364-376 (2014).

    3. Brault, L., Gasser, C., Bracher, F., et al. PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica 95(6), 1004-1015 (2010).