An inhibitor of uric acid reabsorption
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Sulfinpyrazone

Item No. 17847

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione
CAS Number
57-96-5
Synonyms
  • G-28315
  • NSC 75925
Molecular Formula
C23H20N2O3S
Formula Weight
404.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
245 nm
SMILES
O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)C(CCS(C4=CC=CC=C4)=O)C2=O
InChi Code
InChI=1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2
InChi Key
MBGGBVCUIVRRBF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $62

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    10 g

    $103

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    25 g

    $209

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    Product Description

    Sulfinpyrazone is a uricosuric agent that competitively inhibits uric acid (Item No. 16219) reabsorption in kidney proximal tubules, which is a key mechanism targeted in the treatment of gout.1,2 It can also inhibit degranulation of platelets, reducing the release of ADP and thromboxane and diminishing platelet aggregation.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Montgomery, D.B., and Ogryzlo, M.A. Comparison of the uricosuric effect of sulfinpyrazone (anturan) and zoxazolamine (flexin). Can. Med. Assoc. J. 83, 885-888 (1960).

    2. Underwood, M. Diagnosis and management of gout. BMJ 332, 1315-1319 (2006).

    3. Pedersen, A.K., and Jakobsen, P. Sulphinpyrazone metabolism during long-term therapy. Br. J. Clin. Pharmac. 11(6), 597-603 (1981).

    Product Citations

    Rana, P.S., Gibbons, B.A., Vereninov, A.A., et al. Calibration and characterization of intracellular Asante Potassium Green probes, APG-2 and APG-4. Anal. Biochem. 567, 8-13 (2019).