For immunochemical detection of STING
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Alternative(s)
17856STING Monoclonal Antibody (Clone 2C8)
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STING Polyclonal Antibody

Item No. 17857

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Endoplasmic Reticulum Interferon Stimulator
  • ERIS
  • Mediator of IRF3 Activation
  • MITA
  • MPYS
  • Stimulator of Interferon Genes
  • TMEM173
  • Transmembrane Protein 173
Immunogen
Human recombinant STING (Item No. 15139)
Formulation (Request formulation change)
250 µg of Protein A-purified polyclonal antibody
Storage Buffer
TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Host
Rabbit
Applications
ELISA, IP, and WB
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (250 µg)

    $374

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    Product Description

    Stimulator of Interferon Genes (STING) is a component of the innate immune response. STING binds to cyclic dinucleotides, which are bacterial second messengers.1 Recognition of cyclic-di-GMP (c-di-GMP), c-di-AMP, or c-GMP-AMP leads to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).2,3,4 Loss of STING regulation contributes to autoimmune disorders through increased IFN activity.5 The gene for STING is mutated in the mouse strain Goldenticket, which consequently lacks a type I IFN response to Listeria infection.6 Activation of STING by the flavonoid 5,6-dimethylxanthenone-4-acetic acid (DMXAA; Item No. 14617) has been shown to kill solid tumors in mice, but the binding site of DMXAA is not conserved in human STING.7,8

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al. STING is a direct innate immune sensor of cyclic-di-GMP. Nature 478(7370), 515-518 (2011).

    2. Sun, L., Wu, J., Du, F., et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339(6121), 786-791 (2013).

    3. Wu, J., Sun, L., Chen, X., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339(6121), 826-830 (2013).

    4. Konno, H., Konno, K., and Barber, G.N. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155(3), 688-698 (2013).

    5. Gall, A., Treuting, P., Elkon, K.B., et al. Autoimmunity initiates in non-hematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 36(1), 120-131 (2012).

    6. Sauer, J.D., Sotelo-Troha, K., von Moltke, J., et al. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect. Immun. 79(2), 688-694 (2011).

    7. Kim, S., Li, L., Maliga, Z., et al. Anticancer flavonoids are mouse-selective STING agonists. ACS Chem. Biol. 8(7), 1396-1401 (2013).

    8. Gao, P., Ascano, M., Zillinger, T., et al. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell 154(4), 748-762 (2013).