Selectively blocks Tie2 kinase activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tie2 Kinase Inhibitor

Item No. 17858

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-(6-methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine
CAS Number
948557-43-5
Synonyms
  • Tunica Interna Endothelial Cell Kinase 2 Inhibitor
Molecular Formula
C26H21N3O2S
Formula Weight
439.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
234, 322 nm
SMILES
COC1=CC2=C(C=C1)C=C(C3=C(C4=CC=NC=C4)N=C(C5=CC=C(S(C)=O)C=C5)N3)C=C2
InChi Code
InChI=1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H,1-2H3,(H,28,29)
InChi Key
SINQIEAULQKUPD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $44

    Add

    1 mg

    $71

    Add

    5 mg

    $215

    Add

    10 mg

    $387

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM.1 It is 200-fold more potent for inhibition of Tie2 compared to p38.1 Tie2 kinase inhibitor has been shown to reduce angiogenesis in a Matrigel neovascularization assay and to delay tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Semones, M., Feng, Y., Johnson, N., et al. Pyridinylimidazole inhibitors of tie2 kinase. Bioorg. Med. Chem. Lett. 17, 4756-4760 (2007).

    2. Hasenstein, J.R., Kasmerchak, K., Buehler, D., et al. Efficacy of tie2 receptor antagonism in angiosarcoma. Neoplasia 14(2), 131-140 (2012).