A selective CXCR2 inverse agonist
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SB 265610

Item No. 17879

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-urea
CAS Number
211096-49-0
Molecular Formula
C14H9BrN6O
Formula Weight
357.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 3 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.16 mg/mlEthanol: 5 mg/ml
λmax
282, 323 nm
SMILES
BrC1=C(NC(NC2=CC=C(C#N)C3=C2N=NN3)=O)C=CC=C1
InChi Code
InChI=1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
InChi Key
SEDUMQWZEOMXSO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site.1,2 It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Kruijf, P., van Heteren, J., Lim, H.D., et al. Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor. J. Pharmacol. Exp. Ther. 329(2), 783-790 (2009).

    2. Bradley, M.E., Bond, M.E., Manini, J., et al. SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor. Br. J. Pharmacol. 158, 328-338 (2009).

    3. Auten, R.L., Richardson, R.M., White, J.R., et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J. Pharmacol. Exp. Ther. 299, 90-95 (2001).