A lipophilic antioxidant
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Isomer(s)
40267Sinapaldehyde
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Ferulic Acid methyl ester

Item No. 17881

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid, methyl ester
CAS Number
2309-07-1
Synonyms
  • Methyl Ferulate
  • Methyl 4'-hydroxy-3'-methoxycinnamate
Molecular Formula
C11H12O4
Formula Weight
208.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
219, 237, 326 nm
SMILES
COC1=C(O)C=CC(/C=C/C(OC)=O)=C1
InChi Code
InChI=1S/C11H12O4/c1-14-10-7-8(3-5-9(10)12)4-6-11(13)15-2/h3-7,12H,1-2H3/b6-4+
InChi Key
AUJXJFHANFIVKH-GQCTYLIASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    Product Description

    Ferulic acid methyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.1 Ferulic acid methyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 74.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging).2 Ferulic acid methyl ester, at 10-25 µg/ml, inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces nitric oxide generation from LPS-stimulated macrophages.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sultana, R. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders. Biochim. Biophys. Acta 1822(5), 748-752 (2012).

    2. Garrido, J., Gaspar, A., Garrido, E.M., et al. Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress. Biochimie 94(4), 961-967 (2012).

    3. Phuong, N.T.M., Cuong, T.T., and Quang, D.N. Anti-inflammatory ctivity of methyl ferulate isolated from Stemona tuberosa Lour. Asian Pac. J. Trop. Med. 7(Suppl 1), S327-S331 (2014).