Sinapaldehyde

Sinapaldehyde is a phenylpropanoid that has been found in A. altissima and has diverse biological activities.^1,2,3,4,5,6 It is an intermediate in the biosynthesis of the monolignol sinapyl alcohol (Item No. 33916) in angiosperms.² Sinapaldehyde is an inhibitor of farnesyltransferase (FTase; IC₅₀ = 23.99 µM for the rat enzyme).³ It inhibits TNF-α-induced NF-κB transcriptional activity in a reporter assay using HepG2 cells (IC₅₀ = 13.25 µM) and reduces LPS-induced nitric oxide (NO) production in RAW 264.7 cells (IC₅₀ = 5.92 µM).^1,4 Sinapaldehyde scavenges DPPH (Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays (IC₅₀s = 83.02 and 43.15 µM, respectively).⁵ It is active against the Gram-positive bacteria P. pseudomonas, E. coli, and S. enterica (MICs = 64, 128, and 128 µg/ml, respectively) and the Gram-negative bacteria B. cereus, methicillin-sensitive S. aureus (MSSA), and methicillin-resistant S. aureus (MRSA; MICs = 128, 64, and 128 µg/ml, respectively).⁶ It also inhibits α-glucosidase with an IC₅₀ value of 98.81 µM.⁵

WARNING This product is not for human or veterinary use.

1. Kim, H.M., Lee, J.S., Sezirahiga, J., et al. A new canthinone-type alkaloid isolated from Ailanthus altissima swingle. Molecules 21(5), 642 (2016).

2. Li, L., Cheng, X.F., Leshkevich, J., et al. The last step of syringyl monolignol biosynthesis in angiosperms is regulated by a novel gene encoding sinapyl alcohol dehydrogenase. Plant Cell 13(7), 1567-1586 (2001).

3. Sung, N.-D., Cho, Y.K., Kwon, B.M., et al. 3D QSAR studies on cinnamaldehyde analogues as farnesyl protein transferase inhibitors. Arch. Pharm. Res. 27(10), 1001-1008 (2004).

4. Sun, Y.N., Li, W., Song, S.B., et al. NF-κB inhibitory activities of phenolic and lignan components from the stems of Acanthopanax divaricatus var. albeofructus. Nat. Prod. Sci. 20(4), 232-236 (2014).

5. Liu, L., Zou, M., Yin, Q., et al. Phenylpropanoids from Liparis nervosa and their in vitro antioxidant and α-glucosidase inhibitory activities. Med. Chem. Res. 30, 1005-1010 (2021).

6. Lakornwong, W., Kanokmedhakul, K., and Kanokmedhakul, S. A new coruleoellagic acid derivative from stems of Rhodamnia dumetorum. Nat. Prod. Res. 32(14), 1653-1659 (2018).