A histamine H1 receptor antagonist and mast cell stabilizer
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Pemirolast (potassium salt)

Item No. 17889

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-methyl-3-(2H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one, monopotassium salt
CAS Number
100299-08-9
Synonyms
  • BMY 26517
  • TBX
Molecular Formula
C10H7N6O • K
Formula Weight
266.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
211, 259, 364 nm
SMILES
CC1=CC=CN2C1=NC=C(C3=NN=N[N-]3)C2=O.[K+]
InChi Code
InChI=1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1
InChi Key
NMMVKSMGBDRONO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

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    50 mg

    $236

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    100 mg

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    Cayman Chemical
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    Product Description

    Pemirolast is a histamine H1 receptor antagonist and a mast cell stabilizer that prevents the release of histamine.1 It also blocks the release of substance P, neurokinin A, and calcitonin gene-related peptide from sensory nerves.2 Pemirolast has been used for the treatment of allergic conjunctivitis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yanagihara, Y., Kasai, H., Matsui, S., et al. Immunopharmacological studies on TBX, a new antiallergic drug (3). Inhibitory effects on histamine release from lung fragments and bronchoconstriction in guinea pigs. Jpn. J. Pharmacol. 51(1), 83-92 (1989).

    2. Tatsushima, Y., Egashira, N., Kawashiri, T., et al. Involvement of substance P in peripheral neuropathy induced by paclitaxel but not oxaliplatin. J. Pharmacol. Exp. Ther. 337(1), 226-235 (2011).

    3. Minami, K., Hossen, M.A., and Kamei, C. Increasing effect by simultaneous use of levocabastine and pemirolast on experimental allergic conjunctivitis in rats. Biol. Pharm. Bull. 28(3), 473-476 (2005).