A selective RNA polymerase II inhibitor
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α-Amanitin

Item No. 17898

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
23109-05-9
Molecular Formula
C39H54N10O14S
Formula Weight
919.0
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 1mg/ml
λmax
303 nm
SMILES
O=C(N[C@@]1([H])[C@@H](C)[C@@H](O)CO)[C@@]2([H])N(C[C@H](O)C2)C([C@H](CC(N)=O)NC([C@@]([H])(NC(CNC([C@@]([C@H](CC)C)([H])NC(CN3)=O)=O)=O)CS(C4=C(C(C=CC(O)=C5)=C5N4)C[C@@H](C3=O)NC1=O)=O)=O)=O
InChi Code
InChI=1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46
InChi Key
CIORWBWIBBPXCG-JAXJKTSHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $274

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    Product Description

    α-Amanitin is a cyclic peptide found in several species of the Amanita genus as well as other poisonous fungi.1 At 1, 10, and 50 µg/ml, respectively, α-amanitin inhibits RNA polymerase II, III, and IV, preventing translocation of the enzymes on DNA, which significantly slows the rate of transcription.2,3 RNA polymerase I is insensitive to its effects. This toxin is used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hallen, H.E., Luo, H., Scott-Craig, J.S., et al. Gene family encoding the major toxins of lethal Amanita mushrooms. Proc. Natl. Acad. Sci. USA 104(48), 19097-19101 (2007).

    2. Gu, W., Powell, W., Mote, J., Jr., et al. Nascent RNA cleavage by arrested RNA polymerase II does not require upstream translocation of the elongation complex on DNA. The Journal of Biological Chemisty 268(34), 25604-25616 (1993).

    3. Tipper, D.J. Inhibition of yeast ribonucleic acid polymerases by thiolutin. J. Bacteriol. 116(1), 245-256 (1973).