An orally-active CaSR antagonist
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NPS 2143 (hydrochloride)

Item No. 17903

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile, monohydrochloride
CAS Number
324523-20-8
Synonyms
  • SB-262470A
Molecular Formula
C24H25ClN2O2 • HCl
Formula Weight
445.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 2 mg/ml
λmax
225 nm
SMILES
CC(NC[C@@H](O)COC1=C(C#N)C(Cl)=CC=C1)(C)CC2=CC3=CC=CC=C3C=C2.Cl
InChi Code
InChI=1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
InChi Key
ZEBNDUQLNGYBNL-VEIFNGETSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $53

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    5 mg

    $129

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    10 mg

    $180

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    25 mg

    $382

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    Product Description

    NPS 2143 is a potent and selective antagonist of CaSR (IC50 = 43 nM) that stimulates PTH secretion from parathyroid cells in vitro (EC50 = 39 nM).1,2 It is effective in vivo, causing a sustained increase in plasma PTH in rats when given intravenously.1,2 Daily oral administration of NPS 2143 to osteopenic ovariectomized rats results in a dramatic increase in bone turnover, as well as increased circulating PTH levels.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gowen, M., Stroup, G.B., Dodds, R.A., et al. Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats. J. Clin. Invest. 105(11), 1595-1604 (2000).

    2. Nemeth, E.F., DelMar, E.G., Heaton, W.L., et al. Calcilytic compounds: Potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. JPET 299(1), 323-331 (2001).