A Cdk2, Cdk7, and Cdk9 inhibitor
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SNS-032

Item No. 17904

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
CAS Number
345627-80-7
Synonyms
  • BMS-387032
Molecular Formula
C17H24N4O2S2
Formula Weight
380.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 2 mg/mlEthanol: 2.5 mg/ml
λmax
285 nm
SMILES
CC(C)(C)C1=CN=C(CSC2=CN=C(NC(C3CCNCC3)=O)S2)O1
InChi Code
InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
InChi Key
OUSFTKFNBAZUKL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    50 mg

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    Product Description

    SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively.1 It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM).1 SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 µM.2 This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Misra, R.N., Xiao, H.Y., Kim, K.S., et al. N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent. J. Med. Chem. 47(7), 1719-1728 (2004).

    2. Conroy, A., Stockett, D.E., Walker, D., et al. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother. Pharmacol. 64, 723-732 (2009).

    3. Chen, R., Wierda, W.G., Chubb, S., et al. Mechanism of action of SNS032, a novel cyclindependent kinase inhibitor, in chronic lymphocytic leukemia. Blood 113(19), 4637-4645 (2009).