An ellipticine derivative with diverse biological activities
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9-Hydroxyellipticine (hydrochloride)

Item No. 17921

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol, monohydrochloride
CAS Number
52238-35-4
Synonyms
  • 9-OH-Ellipticine
  • NSC 210717
Molecular Formula
C17H14N2O • HCl
Formula Weight
298.8
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly (warmed)Methanol: Slightly
SMILES
CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=C1C=NC=C4.Cl
InChi Code
InChI=1S/C17H14N2O.ClH/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17;/h3-8,19-20H,1-2H3;1H
InChi Key
DLDKVFOKLGPVBT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $160

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    10 mg

    $288

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    25 mg

    $629

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    Cayman Chemical
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    Product Description

    9-Hydroxyellipticine is a derivative of ellipticine (hydrochloride) (Item No. 18742) with diverse biological activities.1,2,3 It inhibits aroclor-induced activation of aniline hydroxylase, aminopyrine N-demethylase, and 7-ethoxycourmarin O-deethylase in rat liver microsomes (Kis = 3.5, 0.6, and 0.74 μM, respectively).1 9-Hydroxyellipticine inhibits the growth of L1210 murine leukemia cells (IC50 = 3 nM) in vitro and increases survival in an L1210 mouse leukemia model.2,3 It inhibits carrageenan-induced edema and UV-induced erythema in guinea pigs.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lesca, P., Rafidinarivo, E., Lecointe, P., et al. A class of strong inhibitors of microsomal monooxygenases: The ellipticines. Chem. Biol. Interact. 24(2), 189-197 (1979).

    2. Monnot, M., Mauffret, O., Simon, V., et al. DNA-drug recognition and effects on topoisomerase II-mediated cytotoxicity. A three-mode binding model for ellipticine derivatives. The Journal of Biological Chemisty 266(3), 1820-1829 (1991).

    3. Le Pecq, J.B., Grosse, C., Dat-Xuong, N., et al. Antitumor activity of 9-hydroxyellipticine (NSC 210717) ON L1210 mouse leukemia and the effect of route of injection. Cancer Res. 36(9 pt. 1), 3067-3076 (1976).

    4. Cros, J., Thibault, A., and Dat-Xuong, N. Anti-inflammatory effect of hydroxy-9-ellipticine. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D. 281(15), 1139-1142 (1975).