A DNA-intercalating antitumor agent
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Ellipticine (hydrochloride)

Item No. 18742

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,11-dimethyl-6H-pyrido[4,3-b]carbazole, monohydrochloride
CAS Number
5081-48-1
Molecular Formula
C17H14N2 • HCl
Formula Weight
282.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 1 mg/ml
λmax
240, 249, 307 nm
SMILES
CC1=C2C(NC3=C2C=CC=C3)=C(C)C4=C1C=NC=C4.Cl
InChi Code
InChI=1S/C17H14N2.ClH/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17;/h3-9,19H,1-2H3;1H
InChi Key
VSBNVARERCGCEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $72

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    10 mg

    $106

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    25 mg

    $246

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    50 mg

    $418

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    Cayman Chemical
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    Product Description

    Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II.1,2,3 It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues.2,3 Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kohn, K.W., Waring, M.J., Glaubiger, D., et al. Intercalative binding of ellipticine to DNA. Cancer Res. 35(1), 71-76 (1975).

    2. Stiborová, M., Poljakova, J., Martinkova, E., et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip. Toxicol. 4(2), 98-105 (2011).

    3. Aimová, D., Svobodová, L., Kotrbová, V., et al. The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism. Drug Metab. Dispos. 35(10), 1926-1934 (2007).