A ROCK1 and ROCK2 inhibitor
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3-(4-Pyridyl)indole

Item No. 17922

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-pyridinyl)-1H-indole
CAS Number
7272-84-6
Synonyms
  • Rho Kinase Inhibitor III
  • ROCK Inhibitor III
  • Rockout
Molecular Formula
C13H10N2
Formula Weight
194.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
221, 314 nm
SMILES
C12=CC=CC=C1NC=C2C3=CC=NC=C3
InChi Code
InChI=1S/C13H10N2/c1-2-4-13-11(3-1)12(9-15-13)10-5-7-14-8-6-10/h1-9,15H
InChi Key
LLJRXVHJOJRCSM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $75

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    25 mg

    $178

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    50 mg

    $312

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    Product Description

    3-(4-Pyridyl)indole is a ROCK1 inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay.1 It also inhibits ROCK2 and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yarrow, J.C., Totsukawa, G., Charras, G.T., et al. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem. Biol. 12(3), 385-395 (2005).