An adenosine receptor antagonist and phosphodiesterase inhibitor
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Dyphylline

Item No. 17958

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
CAS Number
479-18-5
Synonyms
  • 7-(2,3-Dihydroxypropyl)theophylline
  • Dilor
  • Diprophylline
  • Lufyllin
  • Neothyllin
  • NSC 14305
  • NSC 40844
Molecular Formula
C10H14N4O4
Formula Weight
254.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
273 nm
SMILES
CN(C(N1C)=O)C2=C(N(CC(O)CO)C=N2)C1=O
InChi Code
InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3
InChi Key
KSCFJBIXMNOVSH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Dyphylline is a xanthine derivative that acts as an A1 and A2 adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects.1,2 It also moderately inhibits microsomal prostaglandin E synthase-1 with an IC50 value of 200 µM and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cushley, M.J., and Holgate, S.T. Bronchodilator actions of xanthine derivatives administered by inhalation in asthma. Thorax. 40, 176-179 (1985).

    2. Schwabe, U., Ukena, D., and Lohse, M.J. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch. Pharmacol. 330(3), 212-221 (1985).

    3. Ding, R., Shi, J., Pabon, K., et al. Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance. Mol. Pharmacol. 81(3), 328-337 (2012).

    4. Kim, W.I., Choi, K.A., Do, H.S., et al. Expression and purification of human mPGES-1 in E. coli and identification of inhibitory compounds from a drug-library. BMB Reports 41(11), 808-813 (2008).