A selective Cdk7 inhibitor
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BS-181 (hydrochloride)

Item No. 17996

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-pyrazolo[1,5-α]pyrimidine-5,7-diamine, monohydrochloride
CAS Number
1397219-81-6
Molecular Formula
C22H32N6• HCl
Formula Weight
417.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mLDMSO: 25 mg/mLEthanol: 12 mg/mLPBS (pH 7.2): 10 mg/mL
λmax
240, 287 nm
SMILES
CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl
InChi Code
InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27);1H
InChi Key
NVIJWMOQODWNFN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    BS-181 is a Cdk7 inhibitor that blocks the activity of Cdk-activating kinase with an IC50 value of 21 nM.1 It inhibits Cdk2 at a concentration 35-fold higher than that of Cdk7.1 BS-181 has been shown to inhibit the phosphorylation of Cdk7 substrates, to promote cell cycle arrest and apoptosis, to inhibit the growth of cancer cell lines in vitro, and to inhibit the growth of MCF-7 human xenografts in nude mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ali, S., Heathcote, D.A., Kroll, S.H.B., et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69(15), 6208-6215 (2009).