An inhibitor of β-catenin signaling
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FH535

Item No. 18001

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,5-dichloro-N-(2-methyl-4-nitrophenyl)-benzenesulfonamide
CAS Number
108409-83-2
Molecular Formula
C13H10Cl2N2O4S
Formula Weight
361.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/ml
λmax
292 nm
SMILES
ClC1=C(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)C=C(Cl)C=C1
InChi Code
InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
InChi Key
AXNUEXXEQGQWPA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $93

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    25 mg

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    50 mg

    $376

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    Cayman Chemical
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    Product Description

    FH535 is an inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ.1 At 15 µM, FH535 blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ.1 Presumably through these actions, FH535 is selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway.1 FH535 is used to study the role of Wnt/β-catenin pathway in various cancer cell lines.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Handeli, S., and Simon, J.A. A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol. Cancer Ther. 7(3), 521-529 (2008).

    2. Faisy, C., Grassin-Delyle, S., Blouquit-Laye, S., et al. Wnt/ß-catenin signaling modulates human airway sensitization induced by ß2-adrenoceptor stimulation. PLoS One 9(10), (2014).

    3. Su, H., Jin, X., Zhang, X., et al. FH535 increases the radiosensitivity and reverses epithelial-to-mesenchymal transition of radioresistant esophageal cancer cell line KYSE-150R. J. Transl. Med. 13, 104 (2015).

    4. Wu, M.Y., Liang, R.R., Chen, K., et al. FH535 inhibited metastasis and growth of pancreatic cancer cells. Onco Targets Ther. 8, 1651-1670 (2015).