An anticancer agent
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Cycle
G1
Cell Death
Apoptosis

Meisoindigo

Item No. 18007

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one
CAS Number
97207-47-1
Synonyms
  • Methylisoindigotin
Molecular Formula
C17H12N2O2
Formula Weight
276.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/mlDMSO: 1 mg/ml
λmax
270, 388 nm
SMILES
CN(C1=CC=CC=C1/C2=C3C(NC4=C\3C=CC=C4)=O)C2=O
InChi Code
InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9H,1H3,(H,18,20)/b15-14+
InChi Key
QNOCRUSVMMAKSC-CCEZHUSRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Meisoindigo is a derivative of indirubin (Item No. 14155) that has anticancer activity.1 It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Item No. 16069) and idarubicin (Item No. 14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells.2 Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, C.-C., Lin, C.-P., Lee, Y.-L., et al. Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. Leuk. Lymphoma 51(5), 897-905 (2010).

    2. Xiao, Z., Wang, Y., Lu, L., et al. Anti-angiogenesis effects of meisoindigo on chronic myelogenous leukemia in vitro. Leuk. Res. 30(1), 54-59 (2006).