An mTOR activator
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MHY1485

Item No. 18008

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,6-di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
CAS Number
326914-06-1
Molecular Formula
C17H21N7O4
Formula Weight
387.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 0.5 mg/ml
λmax
233, 349 nm
SMILES
O=[N+](C(C=C1)=CC=C1NC2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)[O-]
InChi Code
InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
InChi Key
MSSXBKQZZINCRI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $62

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    10 mg

    $116

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    25 mg

    $222

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    50 mg

    $414

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    Product Description

    MHY1485 is a cell-permeable activator of mTOR that has been shown to increase levels of cellular mTOR Ser2448 and downstream substrate 4E-BP Thr37/46 phosphorylation in rat liver Ac2F cells.1 It can induce cellular LC3-II accumulation in Ac2F cells and has been shown to inhibit autophagy by suppressing the fusion between autophagosomes and lysosomes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Choi, Y.J., Park, Y.J., Park, J.I., et al. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. PLoS One 7(8), e43418 (2012).