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ML-323

Item № 18010
CAS № 1572414-83-5
Purity ≥98%
product image
                (CAS 1572414-83-5)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $74.00 0.00
     10 mg $141.00 0.00
     25 mg $315.00 0.00
     50 mg $592.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

Description

The USP1 deubiquitinating enzyme, which regulates the DNA translesion synthesis (TLS) and Fanconi anemia (FA) DNA damage response pathways by deubiquitinating the central players of these pathways, is activated by the WD40-repeat containing UAF1 protein through formation of a stable USP1-UAF1 protein complex.1 ML-323 is an inhibitor of the USP1-UAF1 deubiquitinase complex with an IC50 value of 76 nM.2 It demonstrates excellent selectivity against other human deubiquitinases, deSUMOylase, deneddylase, and unrelated proteases.2 ML-323 has been shown to inhibit the deubiquitination of proliferating cell nuclear antigen and FA complementation group D2 by inhibiting USP1-UAF1 activity in H596 cells.2 ML-323 potentiates cisplatin (Item No. 13119) cytotoxicity in NSCLC H596 cells and U2OS osteosarcoma cells by targeting the TLS and FA DNA damage response pathways.2

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Technical Information
Formal Name
5-methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine
CAS Number
1572414-83-5
Molecular Formula
C23H24N6
Formula Weight
384.5
Purity
≥98%
Formulation
A crystalline solid
λmax
249 nm
SMILES
CC(C)C1=CC=CC=C1C2=NC=C(C)C(NCC3=CC=C(N4N=NC=C4)C=C3)=N2
InChI Code
InChI=1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
InChI Key
VUIRVWPJNKZOSS-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Kennedy, R.D., and D'Andrea, A.D. The Fanconi Anemia/BRCA pathway: New faces in the crowd Genes & Development 19(24), 2925-2940 (2005).

2. Liang, Q., Dexheimer, T.S., Zhang, P., et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses Nature Chemical Biology 10(4), 298-304 (2014).

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