A hydroxy fatty acid
Related Products
Parent Compound(s)
170379-PAHSA 180229(R)-PAHSA 180239(S)-PAHSA
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9-hydroxy Stearic Acid

Item No. 18016

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-hydroxy-octadecanoic acid
CAS Number
3384-24-5
Synonyms
  • 9-HSA
  • 9-hydroxy Octadecanoic Acid
Molecular Formula
C18H36O3
Formula Weight
300.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
OC(CCCCCCCC(O)CCCCCCCCC)=O
InChi Code
InChI=1S/C18H36O3/c1-2-3-4-5-6-8-11-14-17(19)15-12-9-7-10-13-16-18(20)21/h17,19H,2-16H2,1H3,(H,20,21)
InChi Key
RKHXDCVAPIMDMG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $238

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    10 mg

    $418

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    25 mg

    $913

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    Product Description

    9-hydroxy Stearic acid is a hydroxy fatty acid and an active metabolite of 9-PAHSA (Item No. 17037).1,2 It is formed from 9-PAHSA by liver and pancreatic carboxyl ester lipases.2 9-hydroxy Stearic acid (5 µM) inhibits histone deacetylase 1 (HDAC1) in HT-29 colon cancer cell lysates.3 It inhibits the proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells when used at a concentration of 100 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Calonghi, N., Cappadone, C., Pagnotta, E., et al. 9-Hydroxystearic acid upregulates p21WAF1 in HT29 cancer cells. Biochem. Biophys. Res. Commun. 314(1), 138-142 (2004).

    2. Kolar, M.J., Kamat, S.S., Parsons, W.H., et al. Branched fatty acid esters of hydroxy fatty acids are preferred substrates of the MODY8 protein carboxyl ester lipase. Biochemistry 55(33), 4636-4641 (2016).

    3. Calonghi, N., Cappadone, C., Pagnotta, E., et al. Histone deacetylase 1: A target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. J. Lipid Res. 46(8), 1596-1603 (2005).