For immunochemical detection of fibrinogen
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Fibrinogen (α chain) Polyclonal Antibody

Item No. 18033

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • FGA
Immunogen
Peptide from the C-terminal region of human fibrinogen (α chain)
MW
70 kDa
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2 with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
WB
Cross Reactivity
(+) Fibrinogen (α chain)(-) Fibrinogen (β chain)(-) Fibrinogen (γ chain)
Species Reactivity
(+) Human
UniProt Accession №
P02671
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    Fibrinogen is a hexameric glycoprotein that has roles in coagulation and hemostasis.1,2 It is comprised of two sets of Aα, Bβ, and γ polypeptide chains encoded by FGA, FGB, and FGG, respectively, in humans.1 Fibrinogen is synthesized in hepatocytes and secreted into the plasma. Following thrombin-mediated cleavage of N-terminal fibrinopeptides from the Aα and Bβ chains, yielding the α and β chains, respectively, fibrinogen assembles into fibrin protofibrils and then mature fibers, which provide structure and viscoelasticity to blood clots.2,3,4 Mutations in FGA, FGB, or FGG have been found in patients with afibrinogenemia or hypofibrinogenemia.1 Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disease.5 Immune complexes containing citrullinated fibrinogen have been found in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis.6 Cayman's Fibrinogen (α chain) Polyclonal Antibody can be used for Western blot applications. The antibody recognizes the α chain of fibrinogen at 70 kDa from human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Moerloose, P., Casini, A., and Neerman-Arbez, M. Congenital fibrinogen disorders: An update. Semin. Thromb. Hemost. 39(6), 585-595 (2013).

    2. Pieters, M., and Wolberg, A.S. Fibrinogen and fibrin: An illustrated review. Res. Pract. Thromb. Haemost. 3(2), 161-172 (2019).

    3. Mosesson, M.W. Fibrinogen and fibrin structure and functions. J. Thromb. Haemost. 3(8), 1894-1904 (2005).

    4. Weisel, J.W., and Litvinov, R.I. Fibrin formation, structure and properties. Subcell. Biochem. 82, 405-456 (2017).

    5. Kamath, S., and Lip, G.Y.H. Fibrinogen: Biochemistry, epidemiology and determinants. Q. J. M. 96(10), 711-729 (2003).

    6. Sokolove, J., Zhao, X., Chandra, P.E., et al. Immune complexes containing citrullinated fibrinogen costimulate macrophages via toll-like receptor 4 and Fcγ receptor. Arthritis Rheum. 63(1), 53-62 (2011).