For immunochemical detection of fibrinogen
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Fibrinogen (α chain) Monoclonal Antibody (Clone 6D6)

Item No. 18793

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • FGA
Immunogen
Human fibrinogen (α chain)
Clone Designation
6D6
MW
70 kDa
Formulation (Request formulation change)
100 µg of protein G-purified antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Host
Mouse
Isotype
IgG1
Applications
WB
Species Reactivity
(+) Human
UniProt Accession №
P02671
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 µg

    $347

    Add
    Product Description

    Fibrinogen is a hexameric glycoprotein that has roles in coagulation and hemostasis.1,2 It is comprised of two sets of Aα, Bβ, and γ polypeptide chains encoded by FGA, FGB, and FGG, respectively, in humans.1 Fibrinogen is synthesized in hepatocytes and secreted into the plasma. Following thrombin-mediated cleavage of N-terminal fibrinopeptides from the Aα and Bβ chains, yielding the α and β chains, respectively, fibrinogen assembles into fibrin protofibrils and then mature fibers, which provide structure and viscoelasticity to blood clots.2,3,4 Mutations in FGA, FGB, or FGG have been found in patients with afibrinogenemia or hypofibrinogenemia.1 Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disease.5 Immune complexes containing citrullinated fibrinogen have been found in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis.6 Cayman’s Fibrinogen (α chain) Monoclonal Antibody (Clone 6D6) can be used for Western blot (WB) applications. The antibody recognizes the α chain of fibrinogen at 70 kDa from human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Moerloose, P., Casini, A., and Neerman-Arbez, M. Congenital fibrinogen disorders: An update. Semin. Thromb. Hemost. 39(6), 585-595 (2013).

    2. Pieters, M., and Wolberg, A.S. Fibrinogen and fibrin: An illustrated review. Res. Pract. Thromb. Haemost. 3(2), 161-172 (2019).

    3. Mosesson, M.W. Fibrinogen and fibrin structure and functions. J. Thromb. Haemost. 3(8), 1894-1904 (2005).

    4. Weisel, J.W., and Litvinov, R.I. Fibrin formation, structure and properties. Subcell. Biochem. 82, 405-456 (2017).

    5. Kamath, S., and Lip, G.Y.H. Fibrinogen: Biochemistry, epidemiology and determinants. Q. J. M. 96(10), 711-729 (2003).

    6. Sokolove, J., Zhao, X., Chandra, P.E., et al. Immune complexes containing citrullinated fibrinogen costimulate macrophages via toll-like receptor 4 and Fcγ receptor. Arthritis Rheum. 63(1), 53-62 (2011).