A fluorometric substrate for CYP450-linked enzymes
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Resorufin benzyl ether

Item No. 18077

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(phenylmethoxy)-3H-phenoxazin-3-one
CAS Number
87687-02-3
Synonyms
  • Benzyloxyresorufin
Molecular Formula
C19H13NO3
Formula Weight
303.3
Purity
≥95%
Emission
580 nm
Excitation
570 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/ml
λmax
210, 250, 460 nm
SMILES
O=C1C=CC2=NC(C=CC(OCC3=CC=CC=C3)=C4)=C4OC2=C1
InChi Code
InChI=1S/C19H13NO3/c21-14-6-8-16-18(10-14)23-19-11-15(7-9-17(19)20-16)22-12-13-4-2-1-3-5-13/h1-11H,12H2
InChi Key
XNZRYTITWLGTJS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $145

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    10 mg

    $253

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    Product Description

    Resorufin benzyl ether is a fluorometric probe that acts as a substrate for cytochrome P450 (CYP)3A4.1 It is typically used near its apparent Km value of 30 µM to screen the inhibition/activation potential of test compounds, to predict potential drug-drug interactions, or to monitor other CYP450 activities.1 Upon enzyme cleavage, resorufin is released and displays excitation/emission maxima of 570/580 nm, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stresser, D.M., Blanchard, A.P., Turner, S.D., et al. Substrate-dependent modulation of CYP3A4 catalytic activity: Analysis of 27 test compounds with four fluorometric substrates. Drug Metab. Dispos. 28(12), 1440-1448 (2000).

    2. Hofmann, J., and Sernetz, M. Immobilized enzyme kinetics analyzed by flow-through microfluorimetry: Resorufin-β-D-galactopyranoside as a new fluorogenic substrate for β-galactosidase. Anal. Chim. Acta 163, 67-72 (1984).