Pricing updated 2019-04-24. Prices are subject to change without notice.
3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that plays an important role in growth factor signaling by phosphorylating and activating a group of kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. GSK2334470 is an inhibitor of PDK1 (IC50 = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases, including that of 13 closely related AGC kinase family members.1 In HEK293 cells, 30 nM - 1 µM GSK2334470 suppresses T-loop phosphorylation and activation of SGK, S6K1, and RSK, as well as the activation of Akt.1
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1. Najafov, A., Sommer, E.M., Axten, J.M., et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1 Biochemistry Journal 433(2), 357-369 (2011).