A selective Clk4 inhibitor
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ML-167

Item No. 18098

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol
CAS Number
1285702-20-6
Synonyms
  • CID-44968231
Molecular Formula
C19H17N3O3
Formula Weight
335.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.25 mg/mlEthanol: 0.25 mg/ml
λmax
204, 228, 259, 274, 323 nm
SMILES
CC(O1)=CC=C1CNC2=NC=NC3=C2C=C(C4=CC=C(CO)O4)C=C3
InChi Code
InChI=1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)
InChi Key
ROCFOIBAEVAOLQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $141

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    Product Description

    The Cdc2-like kinases (Clks) and the dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are involved in regulating gene splicing. Clks phosphorylate serine/arginine-rich proteins, which are a major component of the spliceosome, whereas DYRKs interact with and activate splicing factors. ML167 is a selective, ATP-competitive inhibitor of Clk4 with an IC50 value of 136 nM.1 It is more than 10-fold less active against the closely related kinases Clk1-3, DYRK1A, and DYRK1B (IC50s = 1.5, 1.6, >10, >10, and 4.4 µM, respectively), and minimally active against a panel of other kinases.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rosenthal, A.S., Tanega, C., Shen, M., et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). Probe Reports from the NIH Molecular Libraries Program (2010).