A selective Chk1 inhibitor
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SCH 900776

Item No. 18131

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine
CAS Number
891494-63-6
Synonyms
  • MK-8776
Molecular Formula
C15H18BrN7
Formula Weight
376.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 20 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
209, 241, 309, 342 nm
SMILES
NC1=C(Br)C([C@@H]2CCCNC2)=NC3=C(C4=CN(C)N=C4)C=NN31
InChi Code
InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3/t9-/m1/s1
InChi Key
GMIZZEXBPRLVIV-SECBINFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM).1 In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2.1 At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guzi, T.J., Paruch, K., Dwyer, M.P., et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol. Cancer Ther. 10(4), 591-602 (2011).