A 5’-ribonucleoside
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Product Type

Biochemicals
Nucleotides/Nucleosides

Research Area

Inosine-5'-monophosphate (sodium salt hydrate)

Item No. 18135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5'-Inosinic acid, disodium salt octahydrate
CAS Number
20813-76-7
Synonyms
  • IMP
  • Inosinic Acid
Molecular Formula
C10H11N4O8P • 2Na [8H2O]
Formula Weight
536.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
249 nm
SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CNC3=O)O[C@@H]1COP([O-])([O-])=O.[Na+].[Na+].O.O.O.O.O.O.O.O
InChi Code
InChI=1S/C10H13N4O8P.2Na.8H2O/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;;;;;;;;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);;;8*1H2/q;2*+1;;;;;;;;/p-2/t4-,6-,7-,10-;;;;;;;;;;/m1........../s1
InChi Key
QKWLBOYKTJDMLH-NAGQJCCQSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

    $53

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    25 g

    $86

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    100 g

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    Product Description

    Inosine-5'-monophosphate (IMP) is a substrate of IMP dehydrogenase (IMPDH), a NAD+-dependent enzyme that generates xanthosine monophosphate. This is a rate-limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis. Inhibitors of IMPDH, including ribavirin (Item No. 16757) and mycophenolate mofetil (Item No. 13988), have potential applications as antiviral and anti-cancer drugs.1,2,3 5-Ribonucleosides, including IMP, are also involved in potentiating the umami taste sensation.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Watkins, W.J., Chen, J.M., Cho, A., et al. Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH. Bioorg. Med. Chem. Lett. 16(13), 3479-3483 (2006).

    2. Naik, G.S., and Tyagi, M.G. A pharmacological profile of ribavirin and monitoring of its plasma concentration in chronic hepatitis C infection. J. Clin. Exp. Hepatol. 2(1), 42-54 (2012).

    3. Borden, K.L.B., and Culjkovic-Kraljacic, B. Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? Leuk. Lymphoma 51(10), 1805-1815 (2010).

    4. Kinnamon, S.C. Umami taste transduction mechanisms. Am. J. Clin. Nutr. 90(suppl), 753S-755S (2009).