A macrolide antibiotic
Related Products
Labeled Version(s)
33545Tilmicosin-d3
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tilmicosin (phosphate)

Item No. 18190

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4A-O-de(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-tylosin, monophosphate
CAS Number
137330-13-3
Synonyms
  • EL-870
  • LY-177370
Molecular Formula
C46H80N2O13 • H3PO4
Formula Weight
967.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
290 nm
SMILES
CC[C@@H](OC(C[C@@H](O)[C@H](C)[C@@H](O[C@@]1([H])[C@H](O)[C@@H](N(C)C)[C@H](O)[C@@H](C)O1)[C@@H](CCN2C[C@@H](C)C[C@@H](C)C2)C[C@H]3C)=O)[C@@H](CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C=C(C)/C=C/C3=O.O=P(O)(O)O
InChi Code
InChI=1S/C46H80N2O13.H3O4P/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45;1-5(2,3)4/h14-15,19,26-33,35-36,38-4
InChi Key
NESIVXZOSKKUDP-ARVJLQODSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $54

    Add

    25 mg

    $120

    Add

    50 mg

    $209

    Add

    100 mg

    $367

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Tilmicosin is a macrolide antibiotic.1 It is active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 µM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 µM), and inhibits bacterial protein synthesis (IC50 = 0.36 µM). Tilmicosin (75 mg/kg) increases serum creatine kinase (CK), the MB isoform of CK (CK-MB), and malondialdehyde (MDA) levels in mice, indicating cardiotoxicity.2 Formulations containing tilmicosin have been used in the treatment of respiratory diseases in sheep and cattle.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Andersen, N.M., Poehlsgaard, J., Warrass, R., et al. Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Antimicrob. Agents Chemother. 56(11), 6033-6036 (2012).

    2. Kart, A., Yapar, K., Karapehlivan, M., et al. The possible protective effect of ʟ-carnitine on tilmicosin-induced cardiotoxicity in mice. J. Vet. Med. A Physiol. Pathol. Clin. Med. 54(3), 144-146 (2007).