An internal standard for the quantification of tilmicosin
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Unlabeled Version(s)
18190Tilmicosin (phosphate)
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Tilmicosin-d3

Item No. 33545

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4S,5S,6R)-3,5-dihydroxy-6-methyl-4-(methyl(methyl-d3)amino)tetrahydro-2H-pyran-2-yl)oxy)-7-(2-((3S,5R)-3,5-dimethylpiperidin-1-yl)ethyl)-16-ethyl-4-hydroxy-15-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione
CAS Number
2714486-61-8
Molecular Formula
C46H77D3N2O13
Formula Weight
872.2
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
C[C@@H](C[C@H](C1)C)CN1CC[C@@H](C[C@H](C(/C=C/C(C)=C/[C@@H]([C@H](OC(C[C@H]([C@@H]2C)O)=O)CC)CO[C@H]3[C@@H]([C@@H]([C@@H]([C@H](O3)C)O)OC)OC)=O)C)[C@@H]2O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C)O)N(C)C([2H])([2H])[2H])O
InChi Code
InChI=1S/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1/i9D3
InChi Key
JTSDBFGMPLKDCD-VRFNIZQKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Tilmicosin-d3 is intended for use as an internal standard for the quantification of tilmicosin (Item No. 18190) by GC- or LC-MS. Tilmicosin is a macrolide antibiotic.1 It is active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 µM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 µM), and inhibits bacterial protein synthesis (IC50 = 0.36 µM). Tilmicosin (75 mg/kg) increases serum creatine kinase (CK), the MB isoform of CK (CK-MB), and malondialdehyde (MDA) levels in mice, indicating cardiotoxicity.2 Formulations containing tilmicosin have been used in the treatment of respiratory diseases in sheep and cattle.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Andersen, N.M., Poehlsgaard, J., Warrass, R., et al. Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Antimicrob. Agents Chemother. 56(11), 6033-6036 (2012).

    2. Kart, A., Yapar, K., Karapehlivan, M., et al. The possible protective effect of ʟ-carnitine on tilmicosin-induced cardiotoxicity in mice. J. Vet. Med. A Physiol. Pathol. Clin. Med. 54(3), 144-146 (2007).