A PPARα and PPARγ dual agonist
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MHY908

Item No. 18293

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-(5-chloro-2-benzothiazolyl)phenoxy]-2-methyl-propanoic acid
CAS Number
1393371-39-5
Molecular Formula
C17H14ClNO3S
Formula Weight
347.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
217, 310, 324 nm
SMILES
ClC1=CC=C2C(N=C(C3=CC=C(OC(C)(C)C(O)=O)C=C3)S2)=C1
InChi Code
InChI=1S/C17H14ClNO3S/c1-17(2,16(20)21)22-12-6-3-10(4-7-12)15-19-13-9-11(18)5-8-14(13)23-15/h3-9H,1-2H3,(H,20,21)
InChi Key
HJOJVKDSEPDKSE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $53

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    1 mg

    $90

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    5 mg

    $332

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    10 mg

    $559

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    MHY908 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ that increases transcriptional activity of PPARα and PPARγ in a luciferase reporter assay in AC2F rat liver cells when used at a concentration of 5 µM.1 In vivo, MHY908 (3 mg/kg per day) reduces serum glucose, triglyceride, and insulin levels and improves hepatic steatosis by reducing hepatic triglyceride levels and lipid droplet accumulation in db/db mice and 20-month-old rats.1,2 It reduces peroxynitrite and COX-2 levels, reactive oxygen species (ROS) production, and Akt phosphorylation in isolated kidney from 20-month-old rats when administered at a dose of 3 mg/kg.2 MHY908 inhibits mushroom tyrosinase (IC50 = 8.19 µM).3 It also inhibits increases in melanin content in α-melanocyte stimulating hormone-induced B16/F10 murine melanoma cells when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, M.H., Park, J.Y., Lee, H.J., et al. Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice. PLoS One 8(11), e78815 (2013).

    2. Park, M.H., Kim, D.H., Kim, M.J., et al. Effects of MHY908, a new synthetic PPARα/γ dual agonist, on inflammatory responses and insulin resistance in aged rats. J. Gerontol. A Biol. Sci. Med. Sci. 71(3), 300-309 (2016).

    3. Park, M.H., Kim, S.J., Jeong, H.O., et al. Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908). Arch. Pharm. Res. 38(4), 505-511 (2015).