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GSK591

Item № 18354
CAS № 1616391-87-7
Purity ≥95%
product image
                (CAS 1616391-87-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $25.00 0.00
     5 mg $75.00 0.00
     10 mg $138.00 0.00
     25 mg $313.00 0.00

Pricing updated 2019-06-26. Prices are subject to change without notice.

Description
Synonyms
  • EPZ015866
  • GSK3203591

GSK591 is a chemical probe for protein arginine methyltransferase 5 (PRMT5) that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC50 = 11 nM) in vitro. GSK591 is selective for PRMT5 (up to 50 µM) relative to a panel of other methyltransferases. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with an EC50 value of 56 nM. For more information on GSK591 please visit the Structural Genomics Consortium (SGC). The negative control, SGC2096, for GSK591 is also available exclusively through the SGC. You can submit a request to receive the negative control here.

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Technical Information
Formal Name
2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide
CAS Number
1616391-87-7
Synonyms
  • EPZ015866
  • GSK3203591
Molecular Formula
C22H28N4O2
Formula Weight
380.5
Purity
≥95%
Formulation
A crystalline solid
λmax
251, 340 nm
SMILES
O=C(C1=CC(NC2CCC2)=NC=C1)NC[C@H](O)CN3CCC(C=CC=C4)=C4C3
InChI Code
InChI=1S/C22H28N4O2/c27-20(15-26-11-9-16-4-1-2-5-18(16)14-26)13-24-22(28)17-8-10-23-21(12-17)25-19-6-3-7-19/h1-2,4-5,8,10,12,19-20,27H,3,6-7,9,11,13-15H2,(H,23,25)(H,24,28)/t20-/m0/s1
InChI Key
TWKYXZSXXXKKJU-FQEVSTJZSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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