A TRPA1 channel blocker
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TCS 5861528

Item No. 18380

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide
CAS Number
332117-28-9
Molecular Formula
C19H23N5O3
Formula Weight
369.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/mlEthanol: 0.1 mg/ml
λmax
248 nm
SMILES
CN(C(N1C)=O)C2=C(N(CC(NC3=CC=C(C(CC)C)C=C3)=O)C=N2)C1=O
InChi Code
InChI=1S/C19H23N5O3/c1-5-12(2)13-6-8-14(9-7-13)21-15(25)10-24-11-20-17-16(24)18(26)23(4)19(27)22(17)3/h6-9,11-12H,5,10H2,1-4H3,(H,21,25)
InChi Key
ZUTUWJYMCADJHD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $174

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    25 mg

    $392

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    50 mg

    $696

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    Product Description

    TCS 5861528 is a selective TRPA1 blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal (Item No. 32100) with IC50 values of 14.3 and 18.7 μM, respectively.1,2 At 30 mg/kg twice daily in rats, TCS 5861528 has been used to attenuate pain-related behavior in models of diabetic hypersensitivity and postoperative pain.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wei, H., Hämäläinen, M.M., Saarnilehto, M., et al. Attenuation of the mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111, 147-154 (2009).

    2. Fanger, C.M., del Camino, D., and Moran, M.M. TRPA1 as an analgesic target. Open Drug Discov.J. 2, 64-70 (2010).

    3. Wei, H., Karimaa, M., Korjamo, T., et al. Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology 117(1), 137-148 (2012).