A lipid peroxidation product
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Unmodified Version(s)
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4-hydroxy Nonenal

Item No. 32100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)-4-hydroxy-2E-nonenal
CAS Number
75899-68-2
Synonyms
  • FAL 9:1;O
  • 4-HNE
Molecular Formula
C9H16O2
Formula Weight
156.2
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: >50 mg/mlDMSO: >50 mg/mlEthanol: >50 mg/mlPBS pH 7.2: >1 mg/ml
λmax
221 nm
SMILES
CCCCCC(O)\C=C\C=O
InChi Code
InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
InChi Key
JVJFIQYAHPMBBX-FNORWQNLSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $94

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    5 mg

    $374

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    10 mg

    $655

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    Product Description

    4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid.1,2 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation.2 It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.1,2,3 4-hydroxy Nonenal inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic. Biol. Med. 8(6), 541-543 (1990).

    2. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic. Biol. Med. 11(1), 81-128 (1991).

    3. Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Res. 48(2), 320-323 (1988).

    Product Citations

    Song, H., Wohltmann, M., Tan, M., et al. Group VIA phospholipase A2 mitigates palmitate-induced b-cell mitochondrial injury and apoptosis. The Journal of Biological Chemisty 289(20), 14194-14210 (2014).

    Pedersen, W.A., Chan, S.L., and Mattson, M.P. A mechanism for the neuroprotective effect of apolipoprotein E: Isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. J. Neurochem. 74(4), 1426-1433 (2000).