A potent ALK5 inhibitor
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A-77-01

Item No. 18396

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinoline
CAS Number
607737-87-1
Molecular Formula
C18H14N4
Formula Weight
286.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 14 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.04 mg/mlEthanol: 1 mg/ml
λmax
229, 286 nm
SMILES
CC1=NC(C2=NNC=C2C3=CC=NC4=C3C=CC=C4)=CC=C1
InChi Code
InChI=1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H,1H3,(H,20,22)
InChi Key
KJTYZDORHCDZPS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $129

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    10 mg

    $198

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    25 mg

    $347

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    Product Description

    A-77-01 is a potent inhibitor of the TGF-β1 receptor ALK5 (IC50 = 25 nM).1 It has no effects on BMP-regulated transcriptional activity or MAPK pathways. A-77-01 efficiently prevents the growth inhibitory effects of TGF-β on lung epithelial Mv1Lu cells.1 It completely blocks phosphorylation of SMAD2 by TGF-β in human keratinocyte HaCaT cells at 1 µM. A-77-01 prevents morphological and gene expression changes characteristic of epithelial-to-mesenchymal transition in NMuMG cells treated with TGF-β.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tojo, M., Hamashima, Y., Hanyu, A., et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer Sci. 96(11), 791-800 (2005).