An inhibitor of cADP-ribose signaling
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Pro-drug Form(s)
384758-bromo NAD+ (sodium salt)
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cell Signaling
Calcium Mobilization

8-bromo Cyclic ADP-Ribose (sodium salt)

Item No. 18442

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-bromo-1-β-D-ribofuranosyl-adenosine 5'-(trihydrogen diphosphate), intramol. P',5''-ester, disodium salt
Synonyms
  • 8-bromo cADPR
  • 8-bromo cADP-Ribose
Molecular Formula
C15H18BrN5O13P2 • 2Na
Formula Weight
664.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
λmax
213, 265 nm
SMILES
BrC1=NC2=C(N1[C@]3([H])O[C@@]4([H])[C@@H](O)[C@H]3O)N=CN([C@@]5([H])[C@H](O)[C@H](O)[C@](COP(OP(OC4)([O-])=O)([O-])=O)([H])O5)C2=N.[Na+].[Na+]
InChi Code
InChI=1S/C15H20BrN5O13P2.2Na/c16-15-19-6-11(17)20-3-18-12(6)21(15)14-10(25)8(23)5(33-14)2-31-36(28,29)34-35(26,27)30-1-4-7(22)9(24)13(20)32-4;;/h3-5,7-10,13-14,17,22-25H,1-2H2,(H,26,27)(H,28,29);;/q;2*+1/p-2/t4-,5-,7-,8-,9-,10-,13-,14-;;/m1../s1
InChi Key
KHJPKOKHRHVKLB-CZORHFILSA-L
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

    $508

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    Product Description

    8-bromo cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC50 value of 1.7 µM.1 It is commonly used to investigate intracellular signaling through cADP-ribose in isolated cells and tissues.2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, H.C. Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP. Physiol. Rev. 77(4), 1133-1164 (1997).

    2. Bowden, S.E.H., Selyanko, A.A., and Robbins, J. The role of ryanodine receptors in the cyclic ADP ribose modulation of the M-like current in rodent m1 muscarinic receptor-transformed NG108-15 cells. J. Physiol. 519(Pt 1), 23-34 (1999).

    3. Sanz, E., Monge, L., Fernandez, N., et al. Mechanisms of relaxation by urocortin in renal arteries from male and female rats. Br. J. Pharmacol. 140(5), 1003-1007 (2003).

    4. Durnin, L., and Mutafova-Yambolieva, V.N. Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle. FEBS J. 278(17), 3095-3108 (2011).

    5. Park, D.R., Shawl, A.I., Ha, T.G., et al. Arginine thiazolidine carboxylate stimulates insulin secretion through production of Ca2+ - mobilizing second messengers NAADP and cADPR in pancreatic islets. PLoS One 10(8), e0134962 (2015).