A prodrug form of 8-bromo-cADPR
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Active Metabolite(s)
184428-bromo Cyclic ADP-Ribose (sodium salt)
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8-bromo NAD+ (sodium salt)

Item No. 38475

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-bromo-adenosine 5′-(trihydrogen diphosphate), P′→5′-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt, monosodium salt
CAS Number
2022926-16-3
Synonyms
  • N(8-bromo-A)D+
  • 8-bromo Nicotinamide adenine dinucleotide
Molecular Formula
C21H25BrN7O14P2 • Na
Formula Weight
764.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@H]([C@@H]([C@H](O1)COP([O-])(OP([O-])(OC[C@H]([C@H]([C@H]2O)O)O[C@H]2[N+]3=CC(C(N)=O)=CC=C3)=O)=O)O)[C@@H]1N4C5=NC=NC(N)=C5N=C4Br.[Na+]
InChi Code
InChI=1S/C21H26BrN7O14P2.Na/c22-21-27-11-16(23)25-7-26-18(11)29(21)20-15(33)13(31)10(42-20)6-40-45(37,38)43-44(35,36)39-5-9-12(30)14(32)19(41-9)28-3-1-2-8(4-28)17(24)34;/h1-4,7,9-10,12-15,19-20,30-33H,5-6H2,(H5-,23,24,25,26,34,35,36,37,38);/q;+1/p-1/t9-,10-,12-,13-,14-,15-,19-,20-;/m1./s1
InChi Key
OVUYJZJQRPYGFH-XKJOWHJHSA-M
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    7.4 mg

    $208

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    Product Description

    8-bromo NAD+ is a prodrug form of the cyclic ADP-ribose (cADPR) inhibitor 8-bromo cADPR (Item No. 18442).1 It is converted to 8-bromo-cADPR by CD38. 8-bromo NAD+ (1 mM) prevents increases in intracellular calcium levels and chemotaxis induced by N-formyl-Met-Leu-Phe (fMLP; Item No. 21495) in isolated mouse bone marrow-derived neutrophils. It also decreases LPS-induced nitrite production and TNF-α and IL-2 secretion in mouse primary microglial cells when used at a concentration of 100 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Partida-Sánchez, S., Cockayne, D.A., Monard, S., et al. Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Nat. Med. 7(11), 1209-1216 (2001).

    2. Mayo, L., Jacob-Hirsch, J., Amariglio, N., et al. Dual role of CD38 in microglial activation and activation-induced cell death. J. Immunol. 181(1), 92-103 (2008).