An internal standard for the quantification of dabigatran etexilate
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Dabigatran etexilate-d13

Item No. 18451

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[2-[[[4-[[[(hexyl-d13-oxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine, ethyl ester
CAS Number
2749293-92-1
Molecular Formula
C34H28D13N7O5
Formula Weight
640.8
Purity
≥99% deuterated forms (d1-d13)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.5 mg/ml @ 25 degrees C
λmax
223, 322 nm
SMILES
CN1C2=CC=C(C(N(CCC(OCC)=O)C3=NC=CC=C3)=O)C=C2N=C1CNC4=CC=C(C(NC(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=N)C=C4
InChi Code
InChI=1S/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)/i1D3,4D2,6D2,7D2,10D2,21D2
InChi Key
KSGXQBZTULBEEQ-BTQQZDERSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    Product Description

    Dabigatran etexilate-d13 is intended for use as an internal standard for the quantification of dabigatran etexilate (Item Nos. 17131 | 35248) by GC- or LC-MS. Dabigatran etexilate is a prodrug form of the thrombin inhibitor dabigatran (Item No. 17133).1 It inhibits thrombin-induced platelet aggregation in isolated rabbit platelets (IC50 = 0.337 µM) and inhibits thrombus formation in a rat model of venous thrombosis (ED50 = 7.8 µmol/kg). Formulations containing dabigatran etexilate have been used to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation and in the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism.

    WARNING This product is not for human or veterinary use.