A cell-permeable FLT3 inhibitor
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FLT3 Inhibitor

Item No. 18462

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide
CAS Number
301305-73-7
Synonyms
  • Fms-like Tyrosine Kinase Inhibitor
  • TCS 359
Molecular Formula
C18H20N2O4S
Formula Weight
360.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mLDMF:PBS (pH 7.2)(1:3): 0.25 mg/mLDMSO: 3 mg/mL
λmax
220, 256, 349 nm
SMILES
COC1=C(OC)C=CC(C(NC2=C(C(N)=O)C3=C(CCCC3)S2)=O)=C1
InChi Code
InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
InChi Key
FSPQCTGGIANIJZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $297

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    50 mg

    $525

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    Product Description

    FLT3 Inhibitor is a cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 µM).1 It is selective for FLT3 over a panel of 22 other kinases. FLT3 Inhibitor synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patch, R.J., Baumann, C.A., Liu, J., et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg. Med. Chem. Lett. 16(12), 3282-3286 (2006).

    2. Bennett, C.A., Winters, A.C., Barretti, N.N., et al. Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents. Leuk. Res. 33(7), 937-947 (2009).