A synthetic mimic of a riboswitch ligand
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Product Type

Biochemicals
Antibiotics

Research Area

Immunology & Inflammation

Ribocil

Item No. 18487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[1-[[2-(methylamino)-5-pyrimidinyl]methyl]-3-piperidinyl]-6-(2-thienyl)-4(3H)-pyrimidinone
CAS Number
1381289-58-2
Molecular Formula
C19H22N6OS
Formula Weight
382.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 10 mg/mLDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
λmax
244, 313 nm
SMILES
CNC(N=C1)=NC=C1CN2CCCC(C3=NC(O)=CC(C4=CC=CS4)=N3)C2
InChi Code
InChI=1S/C19H22N6OS/c1-20-19-21-9-13(10-22-19)11-25-6-2-4-14(12-25)18-23-15(8-17(26)24-18)16-5-3-7-27-16/h3,5,7-10,14H,2,4,6,11-12H2,1H3,(H,20,21,22)(H,23,24,26)
InChi Key
ZSXCVAIJFUEGJR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $31

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    5 mg

    $139

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    10 mg

    $247

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    25 mg

    $462

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    Product Description

    Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN; Item No. 18167) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB, a gene responsible for the synthesis and transport of riboflavin.1 Ribocil depletes cellular levels of riboflavin with an IC50 value of 0.3 µM and inhibits E. coli growth with an MIC value of 2 µg/ml.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Howe, J.A., Wang, H., Fischmann, T.O., et al. Selective small-molecule inhibition of an RNA structural element. Nature (2015).