A selective EphB4 kinase inhibitor
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NVP-BHG712

Item No. 18489

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]-benzamide
CAS Number
940310-85-0
Molecular Formula
C26H20F3N7O
Formula Weight
503.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/mlEthanol: 2 mg/ml
λmax
257 nm
SMILES
O=C(C1=CC(NC2=C3C(N(C)N=C3)=NC(C4=CN=CC=C4)=N2)=C(C)C=C1)NC5=CC(C(F)(F)F)=CC=C5
InChi Code
InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35)
InChi Key
ZCCPLJOKGAACRT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $196

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    25 mg

    $437

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    Product Description

    NVP-BHG712 is an orally bioavailable inhibitor of EphB4 kinase autophosphorylation (ED50 = 25 nM).1 It is selective for EphB4, demonstrating an ED50 value of 4.2 µM at the related VEGFR2 receptor and ED50 values >10 µM against a panel of 40 additional kinases.1 At 3-30 mg/kg, NVP-BHG712 dose dependently inhibits VEGF-directed vessel formation in an in vivo mouse model of angiogenesis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martiny-Baron, G., Holzer, P., Billy, E., et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis 13, 259-267 (2010).