A dual orexin receptor antagonist
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TCS 1102

Item No. 18495

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-N-[1,1'-biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide
CAS Number
916141-36-1
Molecular Formula
C27H26N4O2S
Formula Weight
470.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7) (1:10): 0.09 mg/mlDMSO: 14 mg/mlEthanol: 10 mg/ml
λmax
205, 284, 291 nm
SMILES
O=C(N1[C@@H](C(NC2=C(C3=CC=CC=C3)C=CC=C2)=O)CCC1)CSC4=NC5=CC=CC=C5N4C
InChi Code
InChI=1S/C27H26N4O2S/c1-30-23-15-8-7-14-22(23)29-27(30)34-18-25(32)31-17-9-16-24(31)26(33)28-21-13-6-5-12-20(21)19-10-3-2-4-11-19/h2-8,10-15,24H,9,16-18H2,1H3,(H,28,33)/t24-/m1/s1
InChi Key
YSBGRVXJEMSEQY-XMMPIXPASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $186

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    25 mg

    $336

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    Product Description

    TCS 1102 is a dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively).1 It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered intraperitoneally.1 Dual orexin receptor antagonists, including TCS 1102, promote sleep and prevent drug-induced plasticity and drug relapse.2 Systemic injection of TCS 1102 (10 mg/kg i.p.) in rats decreases fear and anxiety in response to acute episodes of stress.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bergman, J.M., Roecker, A.J., Mercer, S.P., et al. Proline bis-amides as potent dual orexin receptor antagonists. Bioorg. Med. Chem. Lett. 18(4), 1425-1430 (2008).

    2. Winrow, C.J., Tanis, K.Q., Reiss, D.R., et al. Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology 58(1), 185-194 (2010).

    3. Chen, X., Wang, H., Lin, Z., et al. Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks. Brain Struct. Funct. 219(6), 2103-2118 (2014).