Pricing updated 2019-04-24. Prices are subject to change without notice.
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. CH5424802 is an ATP-competitive inhibitor of ALK (IC50 = 1.9 nM) that also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50s = 1.0, 3.5, and 1.6 nM, respectively).1,2 It shows more than 500-fold selectivity for ALK over a panel of 24 other kinases.1 CH5424802 is orally available and inhibits the growth of tumors in mouse xenograft models of nonsmall cell lung cancer and anaplastic large-cell lymphoma.1
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1. Sakamoto, H., Tskaguchi, T., Hiroshima, S., et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant Cancer Cell 19, 679-690 (2011).
Awad, M.M., and Shaw, A.T. ALK inhibitors in non-