A Met kinase family inhibitor
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BMS-777607

Item No. 18517

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide
CAS Number
1025720-94-8
Synonyms
  • BMS-817378
Molecular Formula
C25H19ClF2N4O4
Formula Weight
512.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2); (1:7): 0.1 mg/mlDMSO: 5 mg/ml
λmax
204, 289 nm
SMILES
NC1=C(Cl)C(OC2=CC=C(NC(C3=C(OCC)C=CN(C4=CC=C(F)C=C4)C3=O)=O)C=C2F)=CC=N1
InChi Code
InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
InChi Key
VNBRGSXVFBYQNN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $157

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    10 mg

    $274

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    50 mg

    $873

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    Product Description

    BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively.1 At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively).1 In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis.1,2 In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharma, S., Zeng, J.Y., Zhuang, C.M., et al. Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents. Mol. Cancer Ther. 12(5), 725-736 (2013).

    2. Dai, Y., and Siemann, D.W. BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro. Mol. Cancer Ther. 9(6), 1554-1561 (2010).