An upregulator of SMN protein
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Cuspin-1

Item No. 18526

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5-bromo-3-pyridinyl)(4-methylphenyl)-methanone
CAS Number
337932-29-3
Synonyms
  • Chemical Upregulator of SMN Protein-1
Molecular Formula
C13H10BrNO
Formula Weight
276.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mLDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 16 mg/mLEthanol: 1 mg/mL
λmax
211, 270 nm
SMILES
CC1=CC=C(C(C2=CC(Br)=CN=C2)=O)C=C1
InChi Code
InChI=1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3
InChi Key
AJZRSLVRFSCCIL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $105

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    25 mg

    $229

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    50 mg

    $423

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    Product Description

    Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 µM.1 Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Letso, R.R., Bauer, A.J., Lunn, M.R., et al. Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins. ACS Chem. Biol. 8(5), 914-922 (2013).