A brain-accessible GABAB receptor antagonist
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CGP 35348

Item No. 18599

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-(3-aminopropyl)-P-(diethoxymethyl)-phosphinic acid
CAS Number
123690-79-9
Molecular Formula
C8H20NO4P
Formula Weight
225.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.1 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CCOC(OCC)P(CCCN)(O)=O
InChi Code
InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)
InChi Key
QIIVUOWTHWIXFO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $183

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    50 mg

    $813

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    Product Description

    CGP 35348 is a selective, brain-accessible GABAB receptor antagonist (IC50 = 34 µM).1 It blocks the action of the GABAB-selective agonist baclofen (Item No. 18600) at postsynaptic sites but not at presynaptic receptors.1,2 CGP 35348 prevents baclofen-induced antinociception and muscle relaxation in mice and rats.3 It is commonly used to investigate the role of GABAB activation in neurological signaling.4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Olpe, H.R., Karlsson, G., Pozza, M.F., et al. CGP 35348: A centrally active blocker of GABA B receptors. Eur. J. Pharmacol. 18791), 27-38 (1990).

    2. Hills, J.M., Larkin, M.M., and Howson, W. A comparison of the relative activities of a number of GABAB antagonists in the isolated vas deferens of the rat. Br. J. Pharmacol. 102(3), 631-634 (1991).

    3. Malcangio, M., Ghelardini, C., Giotti, A., et al. CGP 35348, a new GABAB antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen. Br. J. Pharmacol. 103(2), 1303-1308 (1991).

    4. Koek, W., Cheng, J., and Rice, K.C. Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: Comparison with GABAB receptor agonists and drugs of abuse. J. Pharmacol. Exp. Ther. 344(3), 553-560 (2013).

    5. Gillani, Q., Ali, M., and Iqbal, F. CGP 35348, GABAB receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res. Int. 2014: 295215, (2014).

    6. Ding, L., Gao, R., Xiong, X.Q., et al. GABA in paraventricular nucleus regulates adipose afferent reflex in rat. PLoS One 10(8), (2015).