MBOAT4 Polyclonal Antibody

Membrane bound O-acyl transferases (MBOATs) are a group of conserved, multiple transmembrane spanning enzymes involved in many biological functions including lipid biosynthesis, embryogenesis, nutrient sensing, and membrane lipid remodeling. This group of proteins is associated with pathologies such as diabetes, obesity, atherosclerosis, and Alzheimer’s disease.¹ MBOAT4 is responsible for the octanoylination of ghrelin at serine 3, and can use a number of fatty acids as substrates including octanoic acid, decanoic acid, and tetradecanoic acid.² Increases in the expression of MBOAT4 are dependent on preproghrelin expression during insulin-induced adipogenesis.³ Cayman's MBOAT4 Polyclonal Antibody detects MBOAT in MCF-7 and RT-4 cells by flow cytometry and immunofluorescence in human samples.

WARNING This product is not for human or veterinary use.

1. Chang, C.C.Y., Sun, J., and Chang, T.Y. Membrane-bound O-acyltransferases (MBOATs). Front. Biol. 6(3), 177-182 (2011).

2. Gutierrez, J.A., Solenberg, P.J., Perkins, D.R., et al. Ghrelin octanoylation mediated by an orphan lipid transferase. Proc. Natl. Acad. Sci. USA 105(17), 6320-6325 (2008).

3. Gurriarán-Rodríguez, U., Al-Massadi, O., Crujeiras, A.B., et al. Preproghrelin expression is a key target for insulin action on adipogenesis. J. Endocrinol. 210(2), (2011).