A selective β3-adrenergic receptor agonist
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BRL 37344 (sodium salt)

Item No. 18622

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-acetic acid, monosodium salt
CAS Number
127299-93-8
Synonyms
  • BRL 37344A
Molecular Formula
C19H21ClNO4 • Na
Formula Weight
385.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
218, 274 nm
SMILES
ClC1=CC([C@H](O)CN[C@@H](C)CC2=CC=C(OCC([O-])=O)C=C2)=CC=C1.[Na+]
InChi Code
InChI=1S/C19H22ClNO4.Na/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24;/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24);/q;+1/p-1/t13-,18+;/m0./s1
InChi Key
SNJIJYKMYQRHRC-UFRBEDTPSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $132

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    10 mg

    $238

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    25 mg

    $523

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    Cayman Chemical
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    Product Description

    BRL 37344 is a selective agonist of β3-adrenergic receptors with Ki values of 0.43, 9.17, and 37.9 µM for β3, β2, and β1, respectively.1 β3-Adrenoceptors are expressed in adipose tissue as well as endothelial and myocardial tissues.2 This compound has been used to explore the role of these receptors in the regulation of thermogenesis and lipolysis and to modulate cardiac function in models of cardiovascular disease.3 It has also been used in rodents to study the role that β3-adrenergic receptors play in regulating anxiety-like behaviors.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells. N.-S. Arch. Pharmacol. 369(2), 151-159 (2004).

    2. Kanzler, S.A., Januario, A.C., and Paschoalini, M.A. Involvement of β3-adrenergic receptors in the control of food intake in rats. Braz. J. Med. Biol. Res. 44(11), 1141-1147 (2011).

    3. Niu, X., Zhao, L., Li, X., et al. β3-Adrenoreceptor stimulation protects against myocardial infarction injury via eNOS and nNOS activation. PLoS One 9(6), (2014).

    4. Butler, T.R., Chappell, A.M., and Weiner, J.L. Effect of β3 adrenoceptor activation in the basolateral amygdala on ethanol seeking behaviors. Psychoph. S. 231(1), 293-303 (2014).